Mpox (formerly known as monkeypox) is a rare disease that is caused by infection with the mpox virus/">virus. Mpox can spread to anyone through close, personal, often skin-to-skin contact, including: Direct contact with mpox rash and scabs from a person with mpox, as well as contact with their saliva, upper respiratory secretions (snot, mucus), and areas around the anus, rectum, or vagina/">vagina. This direct contact can happen during intimate contact, including: Oral, anal/">anal, or sex/">vaginal sex, or touching the genitals (penis, testicles/">testicles, labia, and vagina) or anus of a person with mpox: Hugging, massage, and kissing or Prolonged face-to-face contact JYNNEOS is a 2-dose vaccine developed to protect against mpox and smallpox infections. People need to get both doses of the vaccine for the best protection against mpox. The second dose should be given 4 weeks after the first dose.